Margo Panush Cohen, Harold Rifkin's Diabetes and Protein Glycosylation: Measurement and Biologic PDF

By Margo Panush Cohen, Harold Rifkin

ISBN-10: 1461249384

ISBN-13: 9781461249382

ISBN-10: 1461293669

ISBN-13: 9781461293668

In the years because the preliminary discovery that blood from diabetic sufferers includes elevated quantities of a posttranslationally gluco­ sylated kind of hemoglobin (hemoglobin Ale)' a powerful variety of reports have clarified and increased using glycohemoglobin degrees to evaluate illness prestige. Many different structural proteins were proven to suffer related alterations, together with proteins from tissues most ordinarily affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). hence, the nonenzymatic glycosylation of hemoglobin emerges as a useful version for the pathogenesis of definite continual diabetes problems. as well as reviewing a wealth of investigative probabilities within the zone of those continual complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen exhibits how more suitable nonenzymatic glycosylation in out of control diabetes underscores the urgent want for upkeep of long term euglycemia. Dr. Cohen is an endocrinologist and diabetes expert whose learn actions have principally fascinated about the chemistry and metabo­ lism of the basement membrane in diabetes. This excellent monograph on nonenzymatic glycosylation in actual fact exhibits the most important developments of her earlier and current learn and scientific actions. This ebook is fantastically written and a excitement to learn. It offers nice perception into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and may be of huge price not just to uncomplicated and scientific investigators, but in addition to internists, diabetologists, and endocrinologists in scientific practice.

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Gabbay KH, Sosenko 1M, Banuchi GA, et al: Increased glycosylation of hemoglobin A in diabetic patients. Diabetes 1979;28:337-340. 17. Pecoraro RE, Graf RJ, Halter JB, et al: Comparison of a colorimetric assay for glycosylated hemoglobin with ion exchange chromatography. Diabetes 1979;28:1120-1125. 18. Fischer W, deJong C, Voigt E, et al: The colorimetric determination of HbAlc in normal and diabetic subjects. Clin Lab Haematol 1980;2:129138. 19. Subramanian CV, Radhakrishnamurthy B, Berenson GS: Photometric determination of glycosylation of hemoglobin in diabetes mellitus.

70. deBoer MJ, Miedema K, Casparie AF: Glycosylated haemoglobin in renal failure. Diabetologia 1980;18:437-440. 71. Fltlckiger R, Harmon W, Meier W, et al: Hemoglobin carbamylation in uremia. N Engl J Med 1981;304:823-827. 72. Oimoni M, Yoshimura Y, Kubota S, et al: Hemoglobin Al properties of diabetic and uremic patients. Diabetes Care 1981;4:484-486. 73. Stevens VJ, Fantl WJ, Newman CB, et al: Acetaldehyde adducts with hemoglobin. J Clin Invest 1981;67:361-369. Chapter 3 40 74. Brownlee M, Vlassara H, Cerami A:.

67. Koivisto VA, Ekblom M, Icen A, et al: Abnormal hemoglobin variant: A source of error in chromatographic determination of HbAI . Diabetes Care 1982;5:650-651. 68. Nicol DJ, Davis RE, McCann VJ: Hemoglobinopathy in patients with diabetes mellitus: A complicating factor in the measurement of glycosylated hemoglobin, letter to the editor. Diabetes Care 1983;6:524. 69. IRCS Med Sci 1981;9:844-845. 70. deBoer MJ, Miedema K, Casparie AF: Glycosylated haemoglobin in renal failure. Diabetologia 1980;18:437-440.

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Diabetes and Protein Glycosylation: Measurement and Biologic Relevance by Margo Panush Cohen, Harold Rifkin

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