By Charles B. Meinhold
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Additional info for Considerations Regarding the Unintended Radiation Exposure of the Embryo, Fetus, or Nursing Child (Ncrp Commentary)
The evidence is suggestive of no causal relationship between active smoking and breast cancer. 27. Subgroups of women cannot yet be reliably identified who are at an increased risk of breast cancer because of smoking, compared with the general population of women. 28. Whether women who are at a very high risk of breast cancer because of mutations in BRCA1 or BRCA2 genes can lower their risks by smoking has not been established. Chapter 3. Cardiovascular Diseases Smoking and Subclinical Atherosclerosis 1.
For example, it is not possible to actually observe the same human being under identical conditions (including being the same age) except for smoking status. The situation that cannot be observed is called the counterfactual state; literally, counter to the observed facts. The unobservability of the counterfactual state is what makes causal relationships based on observational data subject to uncertainty and questioning. Properly designed studies provide a scientific basis for inferring what the outcome of the counterfactual state would be, and permit related uncertainty to be properly quantified.
The evidence is sufficient to infer a causal relationship between active smoking and the early onset of lung function decline during late adolescence and early adulthood. 10. The evidence is sufficient to infer a causal relationship between active smoking in adulthood and a premature onset of and an accelerated age-related decline in lung function. 11. The evidence is sufficient to infer a causal relationship between sustained cessation from smoking and a return of the rate of decline in pulmonary function to that of persons who had never smoked.
Considerations Regarding the Unintended Radiation Exposure of the Embryo, Fetus, or Nursing Child (Ncrp Commentary) by Charles B. Meinhold