New PDF release: Clusterin in Normal Brain Functions and During

By Caleb Ellicott Finch

ISBN-10: 1570595836

ISBN-13: 9781570595837

Clusterin is a multifunctional protein which used to be independently stumbled on by means of greater than ten diversified examine teams in the Nineteen Eighties. New roles of clusterin in mind services have come to llight that are summarized the following by way of the researchers concerned. fresh discoveries contain a different lipoprotein particle containing clusterin and apoE secreted through astrocytes, and the facility of clusterin to advertise neurotoxic actions of the amyloid beta peptide, but in addition to be neuroprotective. additionally incorporated is contemporary information regarding clusterin and Alzheimer's affliction. In all, this can be a complete and updated overview of clusterin within the mind.

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Biochem J 1993; 293:27-30. 58. Jenne DE, Lowin B, Peitsch MC et al. Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma. J Biol Chem 1991; 266:11030-6. 59. James RW, Hochstrasser AC, Borghini I et al. Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis. Arterioscl Thromb 1991; 11:645-52. 60. Segrest JP, Jackson RL, Morrisett JD et al.

42. Kounnas MZ, Loukinova EB, Stefansson S et al. Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J Biol Chem 1995; 270:13070-5. 43. Zheng G, Bachinsky DR, Stamenkovic I et al. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 1994; 42:531-42. 44. Harr SD, Uint L, Hollister R et al. Brain expression of apolipoproteins E, J, and A-I in Alzheimer’s disease.

J Biol Chem 1983; 258:7714-20. 2. Sylvester S, Skinner MK, Griswold MD. A sulfated glycoprotein synthesized by Sertoli cells and by epididymal cells is a component of the sperm membrane. Biol Reprod 1984; 31:1087-101. 3. Murphy BF, Kirszbaum L, Walker ID et al. Sp-40,40, a newly identified normal human serum protein found in the sc5b-9 complex of complement and in the immune deposits in glomerulonephritis. J Clin Invest 1988; 81:1858-64. 4. Choi-Miura NH, Ihara Y, Fukuchi K et al. SP-40,40 is a constituent of Alzheimer’s amyloid.

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Clusterin in Normal Brain Functions and During Neurodegeneration by Caleb Ellicott Finch


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