Download e-book for kindle: Classics in total synthesis by K. C. Nicolaou

By K. C. Nicolaou

ISBN-10: 3527292314

ISBN-13: 9783527292318

This ebook is a needs to for each artificial chemist. With didactic ability and readability, okay. C. Nicolaou and E. Sorensen current the main awesome and inventive overall syntheses from awesome man made natural chemists.
To make the complicated ideas extra obtainable, specially to the amateur, each one overall synthesis is analyzed retrosynthetically. The authors then conscientiously clarify every one artificial step and provides tricks on replacement tools and capability pitfalls. a number of references to valuable reports and the unique literature make this booklet an vital resource of extra information.
Special emphasis is put on the skillful use of snap shots and schemes: Retrosynthetic analyses, response sequences, and stereochemically an important steps are offered in boxed sections in the textual content. for simple reference, key intermediates also are proven within the margins.
Graduate scholars and researchers alike will locate this publication a gold mine of helpful details crucial for his or her day-by-day paintings. each man made natural chemist should want to have a replica on his or her table.

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Extra resources for Classics in total synthesis

Example text

Introduction. Recently there has been a renewed interest in the study of dynamical structures, and in particular, processes of pattern formation in physical, chemical and biological systems. Unfortunately the under­ standing of such common phenomena as solidification or dendritic growth, which has always been important to metallurgists, is hampered by the mathematical complexity of the problem. Indeed, the process of solidification is equivalent to the Stephan problem: a diffusion problem for the temperature (or impurity concentration) with boundary values specified on the moving interface, the local velocity of which is in turn determined by the heat (or impurity) flux (1).

Assuming t h a t t h e r e l e v a n t p r o c e s s i s c l u s ­ t e r - c l u s t e r a g g r e g a t i o n , and knowing the f r a c t a l s t r u c t u r e , one can e s t i m a t e some i m p o r t a n t p r o ­ p e r t i e s of t h e a g g r e g a t i o n p r o c e s s . One impor­ t a n t q u e s t i o n i s t h e l e n g t h of time t h a t d i f f u ­ s i o n i s t h e dominant mechanism c a u s i n g t h e c l u s ­ t e r s to c o l l i d e . U l t i m a t e l y , the aggregates grow t o s i z e s ^ 5 0 0 urn and p r e c i p i t a t e .

Zsigmondy, Ann. Physik. 15 (1904) 573. 22. M. von Smoluchowski, Phys. Z. 17 (1916) 593. 23. J. C. Stevenson and J. Hillier, Trans. Faraday Soc. Discussion 11 (1951) 55. 24. M. Horisberger, Gold Bull. 14 (1981) 90. 25. A. G. G. Albrecht, J. Chem. Soc. Faraday Trans. II 75 (1979) 790. 26. A. S. A. Weitz, S. W. Kim, J. Phys. Chem. 87 (1983) 4793. 27. S. Alexander, unpublished. 28. K. Sinha, T. Freltoft and J. Kjems, this volume. 29. W. E. Martin, P. S. Cannell, preprint. 30. W. Schaefer, this volume.

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Classics in total synthesis by K. C. Nicolaou

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