By CIBA Foundation Symposium
TGF-beta, initially pointed out as a remodeling development issue with related homes, is referred to now to exist as a relatives of things with comparable homes. those components advertise mobilephone proliferation in a few tissue varieties or stipulations and result in phone differentiation in others. positive aspects the most recent info at the TGF-beta relatives and its receptors. Describes correlations among TGF-beta and likely cancers, together with glioblastomas. additionally comprises stories of initial investigations of scientific functions for TGF-beta in lots of ailments, together with leukemia and its use to speed up wound therapeutic.
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Extra resources for Ciba Foundation Symposium 157 - Clinical Applications of TGF-?
J, Kelly B 1986 Internalization of transforming growth factor-0 and its receptor in BALB/c 3'1'3 fibroblasts. J Cell I'hysiol 128:216-222 Masugu(. J , Like B 1985 CMlular receptors for type 0 transforming growth factor. Ligand binding arid affinity labelling in h u m a n and roden cell lines. 1.. Rodland KCt, Magun HE 198821Transforming growth factor 13 ntodulates epidermal t'actor-induced phosphoinositidc metabolism and intracehlar calciurri levels. I Iiiol Chem 263:5030-5033 Muldoon L L , , Kodland KD, Magun BE 1988b Transforming growth I'actor 0 and epidermal growth factor alter calcium inllux and phosphatidylinositol turiinver in Rat-l fibroblasts.
Or TH2. Sporn: Everybody wonders whether there is sonlethirig peculiarly difficult about this receptor system which explains why, in contrast to many other growth factors receptors, it has not yet been purified to homogeneity and cloned. Patti Segarini mentioned some limitations, but why is this problem particularly difficult? Many extremely capable people are working very hard on this model. We have had homogeneous TGF-P for seven years and we still don’t have a homogeneous cloned receptor. Ruxetti: Some of the other receptor systems that have been cloned have taken a much longer time than has been spent on trying to clone the TCF-P receptor.
32protein found after retinoic acid application in vivo? Is it found predominantly in the epithelial cells or in the mesenchyme? Roberts: The protein is found predominantly in the epithelial cells. 31 RNA expression in areas which seem to be associated with morphogenesis that involves movement of epithelia over mesenchymal cells (Lehnert & Akhurst 1988, Akhurst et a1 1990). Ron Pelton (Pelton et al 1989) has shown that TGF-P2 mRNA is expressed predominantly in differentiating epithelial cells of the skin rather than in those involved in morphogenesis.
Ciba Foundation Symposium 157 - Clinical Applications of TGF-? by CIBA Foundation Symposium