By Bryan M. Turner
I used to be doing crystallography of bacterial and phage proteins. What ever i knew approximately epigenetic regulate used to be lengthy superseded. i wished a entire creation and evaluation in this box. This e-book used to be a superb starter for me. It gave a very good advent and why's and how's of epigenetic regulate of eukaryotic genome and its mechanisms. i'm now eagerly awaiting a moment variation with the entire updates that has occurred within the final 10 years.
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Additional resources for Chromatin and Gene Regulation: Molecular Mechanisms in Epigenetics
Rev. , 60: 689–715. Zawel, L. & Reinberg, D. (1995) Common themes in assembly and function of eukaryotic transcription complexes. Ann. Rev. , 64: 533–561. Chromatin and Gene Regulation: Mechanisms in Epigenetics Bryan M. Turner Copyright © 2001 by Blackwell Publishing Ltd Chapter 3: The Nucleosome: Chromatin’s Structural Unit Introduction All organisms, prokaryotic or eukaryotic, must deal with the problem of packaging a relatively long piece of DNA into a small space within the cell. In eukaryotes, DNA is sequestered in a particular subcellular organelle, the nucleus.
PolI transcribes the genes that encode the major ribosomal RNAs, PolII transcribes the genes encoding the great majority of the cell’s proteins, and PolIII transcribes genes encoding small RNAs such as transfer RNA (tRNA) and small (5S) ribosomal RNAs. The genes encoding the various types of structural and functional RNAs transcribed by Pols I and III are all present in multiple copies (as they are in E. coli) in order to meet the demands of the cell for these components. Remember that for these genes, the RNAs produced are themselves the functional product; there is no further product ampliﬁcation through the process of translation, as occurs with protein-coding genes.
56: 110–156. Genome composition and sequencing Recently, issues of the journals Science and Nature have been devoted to descriptions of the genomes of particular organisms. Speciﬁc articles are cited, but others in the same issues are also of interest. For the most complete and up-to-date information, consult the listed Web sites: Yeast (S. , Barrell, B. , Bussey, H. et al. (1996) Life with 6000 genes. Science, 274: 546–567. Mewes, H. , Bähr, M. et al. (1997) Overview of the yeast genome. Nature, 387: 7–9.
Chromatin and Gene Regulation: Molecular Mechanisms in Epigenetics by Bryan M. Turner