By Michael Caplan (Eds.)
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Extra resources for Cell Biology and Membrane Transport Processes
1988). The multidrug-transporter, a double-edged sword. J . Biol. Chem. 263, 12163-12166. Gottesman, M. , and Pastan, I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385-427. 16 Michael M . G o t t e s m a n et al. Gottesman, M. , Schoenlein, P. , Currier, S. , Bruggemann, E. , and Pastan, I. (1991). Biochemical basis for multidrug resistance in cancer. I n “Biochemical and Molecular Aspects of Selected Cancer” (T. Pretlow and T. ), Vol.
On entry of the nascent polypeptide chain into the lumen of the ER, the signal peptide is usually cleaved (Dev and Ray, 1990). , 1988; Langer and Neupert, 1991). Once properly assembled in the ER lumen, secreted proteins are delivered to their final destination by packaging in transport vesicles. It is the formation (“budding”), movement, and refusion (“targeting”) of the vesicles that sorts and conveys secretory proteins from the ER to the Golgi, through the Golgi cisternae, and finally to the plasma membrane (Balch, 1990).
Kyle, D. , Martin, R. , Oduola, A. M. , Kemp, D. , and Cowman, A. F. (1990). Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparium. Nature (London) 345, 255-258. , and Ling, V. (1991). Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein. J. Cell. Physiol. 148, 479-484. , and Pastan, I. (1988). The multidrug-transporter, a double-edged sword. J . Biol. Chem. 263, 12163-12166. Gottesman, M. , and Pastan, I.
Cell Biology and Membrane Transport Processes by Michael Caplan (Eds.)