Download PDF by Clifford P Stanners: Cell adhesion and communication mediated by the CEA family :

By Clifford P Stanners

ISBN-10: 0203304217

ISBN-13: 9780203304211

ISBN-10: 9057022907

ISBN-13: 9789057022906

Considers the new explosion of data in regards to the carcinoembryonic antigen (CEA) family members, which resulted from the molecular cloning of loved one genes in 1986.
Results indicating CEA kinfolk upregulated in melanoma may have an instrumental function in malignant transformation and metastasis, whereas those who are downregulated may have tumor suppressive features are thought of. studies, fresh effects, hypotheses, and scientific purposes concerning a gene kin that, from its frequent alterations in expression in tumors at many websites, might be considered as a "major participant" in human melanoma also are mentioned. the traditional services reminiscent of epithelial and hematopoietic adhesion and signalling molecules are explored, and the potentially certain function of this relations in evolution is brought.
This quantity may be of curiosity to researchers within the fields of intercellular adhesion, evolution, and molecular reputation, in addition to clinicians attracted to the new wisdom relating to a tumor marker generally utilised within the health facility, and firms wishing to take advantage of this cancer-related kinfolk for novel advertisement functions within the biomedical sphere.

Show description

Read or Download Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives PDF

Best cell biology books

Get Spirulina Platensis Arthrospira: Physiology, Cell-Biology PDF

Spirulina Platensis, a blue-green algae, has been famous and used around the globe as a conventional resource of protein within the foodstuff undefined. The makes use of and mass cultivation of this algae have risen considerably because of an elevated realizing of its organic structures. ; this article includes distinctive descriptions of either the biology and the biotechnological makes use of of Spirulina Platensis.

Download PDF by M. A. Hayat: Colloidal Gold. Principles, Methods, and Applications

Due to the fact that its advent in 1971, the improvement and alertness of colloidal gold as a marker in electron microscopy has been extraordinary. This state-of-the paintings, multi-volume treatise offers researchers, technicians, academics, and scholars with the main complete assurance of the foundations and method of colloidal gold microscopy to be had this present day.

Working with Stem Cells - download pdf or read online

The content material lined surround not just the theoretic and methodological elements for culturing human pluripotent stem cells, but additionally the institution of prompted pluripotent stem cells and their differentiation into particular mobile subtypes. This e-book has the main up to date equipment and applied sciences in an obtainable and transparent language, offering protocols constructed and optimized through researchers that use them on a daily basis.

Read e-book online Black Rice: Research, History and Development PDF

The most function of this booklet is to introduce black rice to a much wider circle of individuals. even supposing there were learn on various points of black rice, the knowledge is scattered and never simply obtainable to laypersons. The booklet intends to hide the entire facets of black rice from examine, background, to its improvement.

Extra info for Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives

Sample text

HAMMARSTRÖM ET AL. including an Alulike element as an expressed exon (Figure 5). The functional significance of all these variants is not yet fully understood, less so if they are regulated in any way. , 1995), which suggest that BGP might be linked to a signal transduction pathway. BGP is named CD66a in the CD nomenclature. CEA gene family member 1 (CGM1) CGM1 is composed of only one Ig-like domain (N; Figure 5) with a transmembrane domain and a cytoplasmic tail. The N-domain is 89% identical at the amino acid level to the N-domain of either CEA, BGP, or NCA.

CGM2 was expressed in some epithelial cancers notably mucinous ovarian carcinoma, while the granulocyte-associated molecules CGM6, CGM1 and CGM7 were not detected in any of the tumors of epithelial origin investigated. , 1995). Interestingly, mRNA for CEA and NCA50/90 were expressed to a similar degree in normal and tumor tissue while BGP mRNA was expressed at a lower level in colon tumors as compared to normal colon mucosa. Cytokeratine 18 mRNA was used to normalize the measurements for differences in epithelial cell content.

The cell- and regionspecific expression patterns of CEA-, NCA50/90- and BGP glycoproteins were in complete agreement with the findings at the mRNA level (Figure 7) indicating that the production of these glycoproteins is controlled at the transcriptional level. Maximum expression of CEA, NCA50/90 and BGP and their mRNAs was attained only when the columnar cell had migrated up to the level of the free luminal surface, that is to the functional compartment of the colonic mucosa. We expect that this will also be the case for CGM2.

Download PDF sample

Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives by Clifford P Stanners

by Robert

Rated 4.07 of 5 – based on 34 votes