By Clifford P Stanners
Considers the new explosion of data in regards to the carcinoembryonic antigen (CEA) family members, which resulted from the molecular cloning of loved one genes in 1986.
Results indicating CEA kinfolk upregulated in melanoma may have an instrumental function in malignant transformation and metastasis, whereas those who are downregulated may have tumor suppressive features are thought of. studies, fresh effects, hypotheses, and scientific purposes concerning a gene kin that, from its frequent alterations in expression in tumors at many websites, might be considered as a "major participant" in human melanoma also are mentioned. the traditional services reminiscent of epithelial and hematopoietic adhesion and signalling molecules are explored, and the potentially certain function of this relations in evolution is brought.
This quantity may be of curiosity to researchers within the fields of intercellular adhesion, evolution, and molecular reputation, in addition to clinicians attracted to the new wisdom relating to a tumor marker generally utilised within the health facility, and firms wishing to take advantage of this cancer-related kinfolk for novel advertisement functions within the biomedical sphere.
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Extra info for Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives
HAMMARSTRÖM ET AL. including an Alulike element as an expressed exon (Figure 5). The functional significance of all these variants is not yet fully understood, less so if they are regulated in any way. , 1995), which suggest that BGP might be linked to a signal transduction pathway. BGP is named CD66a in the CD nomenclature. CEA gene family member 1 (CGM1) CGM1 is composed of only one Ig-like domain (N; Figure 5) with a transmembrane domain and a cytoplasmic tail. The N-domain is 89% identical at the amino acid level to the N-domain of either CEA, BGP, or NCA.
CGM2 was expressed in some epithelial cancers notably mucinous ovarian carcinoma, while the granulocyte-associated molecules CGM6, CGM1 and CGM7 were not detected in any of the tumors of epithelial origin investigated. , 1995). Interestingly, mRNA for CEA and NCA50/90 were expressed to a similar degree in normal and tumor tissue while BGP mRNA was expressed at a lower level in colon tumors as compared to normal colon mucosa. Cytokeratine 18 mRNA was used to normalize the measurements for differences in epithelial cell content.
The cell- and regionspecific expression patterns of CEA-, NCA50/90- and BGP glycoproteins were in complete agreement with the findings at the mRNA level (Figure 7) indicating that the production of these glycoproteins is controlled at the transcriptional level. Maximum expression of CEA, NCA50/90 and BGP and their mRNAs was attained only when the columnar cell had migrated up to the level of the free luminal surface, that is to the functional compartment of the colonic mucosa. We expect that this will also be the case for CGM2.
Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives by Clifford P Stanners