By Bernhard Voykowitsch
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In summary, anthracycline antibiotics stimulate an oxygen radical cascade by several different mechanisms throughout cardiac myocytes. Toxic effects of the strongly oxidizing species that are produced include inhibition of mitochondrial ATP production 39 and the sarcotubular calcium pump, as well as oxyradical-related changes in membrane integrity. The widespread nature of the reactive oxygen formation produced by anthracyclines in the heart and the critical functions impaired by these reactions strongly suggest that redox cycling of the anthracycline quinone plays an important part in the cardiac toxicity of these drugs.
Castiglione 1796: Napoleon Repulses Wurmser's First Attack by Bernhard Voykowitsch