Download PDF by Bernhard Voykowitsch: Castiglione 1796: Napoleon Repulses Wurmser's First Attack

By Bernhard Voykowitsch

ISBN-10: 3901923004

ISBN-13: 9783901923005

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9. A. (1983) Biochem. 22: 2645-2649. , and Norskov-Lauritsen, N. (1986) FEBS Lett. 10. 196: 321-323. 11. V. J. (1975) Nature 255: 87-88. J. and Frieden, E. (1978) Biochem. 17: 167-172. 12. Van Renswoude, J. B. and Klaus13. D. (1982) Proc. Natl. Acad. Sci. USA. 79: 6186-6190. 14. R. and Maxfield, F. R. (1984) Cell 37: 789-800. 15. F. (1984) FEBS Lett. 176:97-100. 16. Thomas, C. , and Aust, S. D. (1986) Arch. Biochem. Biophys. 248: 684-689. 17. , Gianni, L. and Myers, C. E. (1984) Biochem. 23: 928936.

H. (1985) Biochem. Biophys. Res. Commun. 130: 739-745. 11. H:-(1983) Cancer Res. 43: 460-472. 12. H. A. 1I986) J. Biol. Chern. 261: 3068-3074. 13. Glick. R •• Burns. H. and Reddy. J. (1974) Analyt. Biochem. 61: 32-42. 14. A. F. (1981) Cell and Tissue Res. 216: 231-251. 15. A. H. (1986) J. Biol. Chern. 261: 3060-3067. 16. J. (1978) Cancer Treat. Rep. 62: 955-961. 17. H. (1983) Proc. Amer. lCancer Res. 24: 255. 18. Doroshow. H. (1987) Proc. Amer. Assoc. Cancer Res. 28: 262. 19. H. (1986) Proc. Amer.

In summary, anthracycline antibiotics stimulate an oxygen radical cascade by several different mechanisms throughout cardiac myocytes. Toxic effects of the strongly oxidizing species that are produced include inhibition of mitochondrial ATP production 39 and the sarcotubular calcium pump, as well as oxyradical-related changes in membrane integrity. The widespread nature of the reactive oxygen formation produced by anthracyclines in the heart and the critical functions impaired by these reactions strongly suggest that redox cycling of the anthracycline quinone plays an important part in the cardiac toxicity of these drugs.

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Castiglione 1796: Napoleon Repulses Wurmser's First Attack by Bernhard Voykowitsch


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