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177. 178. 179. 180. 181. 182. 183. 184. 185. 186. 187. 188. 189. 190. 191. 192. 193. 194. 195. 196. 197. 198. 199. 200. 201. 202. 203. 204. 205. , Teslova 30, 1000 Ljubljana, Slovenia Boehringer Ingelheim Austria GmbH, Dr. Boehringer Gasse 5–11, 1121 Vienna, Austria Monolithic supports represent a novel type of stationary phases for liquid and gas chromatography, for capillary electrochromatography, and as supports for bioconversion and solid phase synthesis. As opposed to individual particles packed into chromatographic columns, monolithic supports are cast as continuous homogeneous phases.

82 1 Introduction The developments in molecular and cell biology in the last quarter of the 20th century led to new technologies for the production of complex biomolecules which have the potential to assist in human health care in the areas of diagnostics, prevention and treatment of diseases. One of the most important and at the same time most expensive step in their production is the isolation and cleaning (down-stream processing) of the target biomolecule(s).

44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. F. Svec Schmeer K, Behnke B, Bayer E (1995) Anal Chem 67:3656 Boughtflower RJ, Underwood T, Maddin J (1995) Chromatographia 41:398 Dittmann MM, Wienand K, Bek F, Rozing GP (1995) LC-GC 13:800 Crego AL, Gonzalez A, Marina ML (1996) Crit Revs Anal Chem 26:261 Colon LA, Reynolds KJ, Maldonado RA, Fermier A (1997) Electrophoresis 17:2162 Robson MM, Cikalo MG, Myers P, Euerby MR, Bartle KD (1997) J Microcol Sep 9:357 Altria KD, Smith NW, Turnbull CH (1997) Chromatographia 46:664 Rathore AS, Horvath C (1997) J Chromatogr A 781:185 Cikalo MG, Bartle KD, Robson MM, Myers P, Euerby MR (1998) Analyst 123:87R Krull IS, Stevenson R, Mistry K, Schwarz ME (2000) Capillary electrochromatography and pressurized flow capillary electrochromatography: an introduction.

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Capillary Electrochromatography by Svec Frantisek

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