By Otmar D. Wiestler, Bernhard Haendler, D. Mumberg
Cancer stem cells have initially been pointed out in leukemia and later in numerous sturdy tumor kinds. they've got very diverse homes from the majority of the tumor as they divide even more slowly and feature very effective drug resistance mechanisms. present remedies may possibly mostly spare melanoma stem cells. This e-book appears to be like at fresh advancements within the box of melanoma stem cells and the potential influence for the id of novel therapy paradigms for cancer.
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Additional resources for Cancer stem cells : novel concepts and prospects for tumor therapy
Furthermore, their data suggest that these double-positive cells with their stem cell-like features may play an important role in the transformation of normal lung epithelia into adenocarcinomas (Kim et al. 2005). However, there are questions that still need to be answered, such as whether these bronchioalveolar stem cells give rise to lung cancer stem cells, and if so, what events are required to achieve this transformation. The activation of Hh and Wnt pathways in promoting stem cell renewal, transiently in normal tissues and aberrantly in carcinogenesis, has attracted great scientific interest.
2005) found that Wnt-5a expression in squamous cell carcinoma was significantly higher than that in adenocarcinoma. Furthermore, this study revealed that Wnt-5a overexpression could produce more aggressive NSCLC, especially in squamous cell carcinomas, during tumor progression. 2 Wnt Antagonists There are two groups of Wnt antagonists. The first includes the SFRP family, WIF-1 and Cerberus. They inhibit Wnt signaling by directly binding to Wnt molecules. The second group, which includes the Dickkopf (DKK) family, inhibits Wnt signaling by binding to the LRP5/ LRP6 component of the Wnt receptor complex (Kawano and Kypta 2003).
Treatment of isolated HSCs with Wnt proteins in vitro increases their proliferative capacity and improves their ability to form colonies, both in vitro and in vivo (Reya et al. 2003). While inhibiting Wnt pathway activation in the intestine fails to prevent the development, initially, of normal epithelial architecture, its inactivation eventually results in a progressive degradation of epithelial structure. This effect is associated with a loss of proliferative activity in the crypts, where stem cells reside (Korinek et al.
Cancer stem cells : novel concepts and prospects for tumor therapy by Otmar D. Wiestler, Bernhard Haendler, D. Mumberg