By Carlos A. Zarate Jr., Husseini K. Manji
Even if our wisdom of temper problems usually is increasing gradually, relatively little is understood approximately bipolar melancholy specifically. This ebook brings jointly top clinicians and preclinical and medical researchers to provide the main up to date information regarding the prognosis, remedy, and examine surrounding bipolar melancholy. Early chapters offer precious diagnostic info, and assessment the direction, final result, and genetics of this hugely heritable , permitting clinicians to differentiate among some of the temper problems. The booklet bargains a radical and precise assessment of the neurobiology of the ailment, together with what's identified from contemporary neuroimaging paintings. numerous chapters delineate the therapy of bipolar melancholy in detailed populations equivalent to childrens and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, targeting the necessity for evaluate in the course of either acute and upkeep remedy with interventions applicable to a patient's indicators and heritage. ultimately, the e-book covers acute and long term remedy techniques for bipolar melancholy, together with either conventional and novel therapeutics for the disease, in addition to non-pharmacological remedies. This e-book has assembled a greatly revered workforce of preclinical and medical researchers who convey their services to undergo upon this disease. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating illness.
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Extra info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)
Most measures assessing depressive phenomenology rate symptoms in terms of their severity (whether self-reported or observer-rated). We have recently completed a study in which patients attending our Depression Clinic were asked to rate their most recent and/or severe depressive episode in terms of its characteristic features. While these results will be reported elsewhere, we will review here the findings of relevance to this chapter. We examined the most characteristic symptoms as nominated by those with (i) bipolar depression (n = 123), (ii) unipolar melancholia (n = 86), and (iii) unipolar non- melancholic depression (n = 142).
In this chapter we will summarize the main factors predicting course and outcome in bipolar disorder with a focus on depressive symptoms. The natural course, the impact of the first episode, the impact of the depressive phase, cycle length, age of onset, age, gender, type of illness, personality traits and temperament, co-morbidity, family history, life events, and outcome features will be reviewed. Conceptual models such as staging and outcome dimensions and their prognostic value will also be discussed.
When comparing BPD and unipolar subjects, the former group were significantly more likely to be diagnosed as having a melancholic depression by DSM-IV criteria (69% versus 37%), by the CORE measure  (59% versus 33%), and by clinical definition (70% versus 29%). We undertook logistic regression analyses examining a large number of clinical features, and found that observable psychomotor disturbance (particularly retardation) and pathological guilt were the only two significantly overrepresented features in those with BPD during the depressed phase.
Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy) by Carlos A. Zarate Jr., Husseini K. Manji