Biopsy Interpretation of the Central Nervous System by Matthew J. Schniederjan MD, Daniel J. Brat MD PhD PDF

By Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

ISBN-10: 0781799937

ISBN-13: 9780781799935

This can be a sensible advisor and concise reference that may be a significant other textual content for the final surgical pathologist, trainees in pathology and neuropathology, and clinicians who deal with sufferers with neurological ailments that require surgical sampling.

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2000;55(6):811–5. 75. , MRI lesion profiles in sporadic Creutzfeldt-Jakob disease. Neurology. 2009;72(23):1994–2001. 76. Brown, P, A Wolff, and DC Gajdusek, A simple and effective method for inactivating virus infectivity in formalin-fixed tissue samples from patients with Creutzfeldt-Jakob disease. Neurology. 1990;40(6):887–90. 77. , Patients with Alzheimer’s disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2001;71(1):33–9. 78. , Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).

63. , Progressive multifocal leukoencephalopathy in AIDS: initial and follow-up CT and MRI. Neuroradiology. 1997;39(9):611–8. 38 ——— BIOPSY INTERPRETATION OF THE CENTRAL NERVOUS SYSTEM 64. , Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation. Radiology. 1993; 187(1):233–40. 65. , Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study. Clin Infect Dis. 2009;48(10):1459–66.

Neuroimaging by magnetic resonance (MR) shows a poorly defined lesion with mild T1-hypointensity and T2-hyperintensity that often advances along white matter tracts (Figure 3-1). Increased T2 signal is thought to mark the presence of edema in areas infiltrated by tumor. Gadolinium contrast material has no effect in grade II astrocytomas, but it causes enhancement in a subset of grade III cases [5]. A lack of contrast enhancement does not rule out the possibility of an anaplastic lesion. The tumor’s epicenter usually lies within the white matter.

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Biopsy Interpretation of the Central Nervous System by Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

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