Biophysical Aspects of Cerebral Circulation - download pdf or read online

By Yu. E. Moskalenko

ISBN-10: 0080226728

ISBN-13: 9780080226729

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Extra info for Biophysical Aspects of Cerebral Circulation

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13). Calculations of local cerebral blood flow based on the above equations have made it possible to elaborate various modified methods which mainly differ in the type of indicator used and the method of saturating the brain with it. Two types of indicator are used to record the regional cerebral blood flow. These are nondiffusable and diffusable indicators. With the exception of hydrogen, they are all radioactive isotopes of inert gases or isotopes of biologically inactive chemical elements. Therefore the same method of recording clearance is used for all isotope indicators.

In addition, it requires recording on a logarithmic scale. The Potentiometrie determination of hydrogen in the brain is not widely used because it was shown shortly after its introduction that the current in the circuit consisting of the coated platinum and calomel electrodes and low external resistance is Unearly dependent on the hydrogen concentration in the region of recording (Hyman, 1961). Although this circuit differs from the usual Polarographie one in that it lacks an external source of current, it is evident that a Polarographie mechanism gives rise to the current in such a circuit (Aukland, 1965).

If this compensatory change in venous volume is regarded as an overflow from a reservoir (the venous system) through a small opening with an area S in the presence of excess pressure ΔΡ3, then the volume rate of the overflow can be determined by the following equation (Kiselev, 1963). 62S llg-^^ (32) where g is the gravitational acceleration and y is the specific gravity of blood. Thus, the volume rate of blood flow at the output of the venous blood stream q is determined by the volume rates u and Awvc, The sign of Awvc is the same as ΔΡ3.

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Biophysical Aspects of Cerebral Circulation by Yu. E. Moskalenko


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