By Arnold J. Rudolph, Arnold J. Rudol, Arnold J. Rudolph MD
Colour atlas of neonatology. quantity of a 5 quantity set masking a whole variety of dermatologic, cardiac, pulmonary, gastrointestinal, genitourinary, neurologic, and musculoskeletal problems, genetics, and syndromes.
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Extra resources for Atlas of the Newborn. Musculoskeletal Disorders
97 The effects produced by the function-blocking antibodies were partial and delayed compared to those achieved with RGD peptides. This opens the interesting possibility that LTP goes through more than one integrin-dependent consolidation stage. An early stage involving integrins other than α5 or α3 would, according to this argument, produce a long-lasting but slowly decremental LTP that can be largely reversed. A slightly later stage of consolidation would be expected to incorporate contributions from the α3β1 and α5β1 integrins and to 20 Recent Advances in Epilepsy Research result in a potentiation that is both stable and extremely resistant to interference.
161 These findings suggest that synaptic integrins may also be substrates for activity-regulated serine protease activity in brain but there is, as yet, no information on this point. In additional to the trypsin-like proteases, seizures increase the expression and activities of metalloproteinases (MMPs) in brain. 165 Thus, seizures appear to stimulate a controlled MMP-mediated proteolysis of the ECM in adult brain. Given the involvement of MMPs in modifying the extracellular environment to facilitate growth and cellular migration in peripheral tissues and brain,166 the possibility that these enzymes facilitate axonal growth and, in particular, seizure-induced sprouting and synaptogenesis in hippocampus is particularly attractive.
Hynes R. Integrins, versatility, modulation, and signaling in cell adhesion. Cell 1992; 69:11-25. 47. Mould AP. Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes. J Cell Sci 1996; 109:2613-2618. 48. Humphries MJ, Delwel GO, Kuikman I et al. Integrin structure. Biochem Soc Trans 2000; 28:311-39. 49. Hynes RO. Cell adhesion: old and new questions. Trends Cell Biol 1999; 9:M33-M37. 50. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285:1028-1032.
Atlas of the Newborn. Musculoskeletal Disorders by Arnold J. Rudolph, Arnold J. Rudol, Arnold J. Rudolph MD