Get Asthma: Immunopathology and Immunotherapy / Immunopathologie PDF

By Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke (auth.), Univ.-Prof. Dr. Friedrich Kummer (eds.)

ISBN-10: 3211824545

ISBN-13: 9783211824542

ISBN-10: 3709175372

ISBN-13: 9783709175378

Das Konzept des allergischen bronchial asthma hat lange Zeit so sehr dominiert, da? die Immunotherapie vielfach ohne gesicherte diagnostische Grundlage, halbherzig oder ohne die Feinheiten der Allergenvermeidung angewendet wurde. Die Forschung der letzten zehn Jahre hat uns eine derartige Ausweitung unseres Wissenshorizontes beschert, da? es an der Zeit schien, ma?gebliche Autoren zur gemeinsamen Diskussion der neuen Aspekte einzuladen. Das Buch berichtet von den neuesten Erkenntnissen uber zellulares Verhalten, unterschiedliche Zytokinmuster und autoimmunologische Aspekte bis hin zur modernen Allergenvermeidung, aber auch von der wirksamen medikamentosen Therapie der eosinophilen Entzundung the concept that of bronchial asthma being an "allergic ailment purely" has ruled above others to an quantity, re-examination of this factor within the gentle of very contemporary effects from learn in immunopathology appeared greater than past due. This quantity presents a present inspiration of idea and medical perform of immunopathology and treatment of bronchial asthma, comprising huge and fresh laboratory information on atopy, intrinsic bronchial asthma, points of autoimmunology, in addition to instructions for allergen avoidance, immunotherapy and - final no longer least - pharmacological therapy of eosinophilic irritation.

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Extra info for Asthma: Immunopathology and Immunotherapy / Immunopathologie und Immunotherapie

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Previous studies on blood eosinophils from asthmatics have also demonstrated a significant proportion of hypo dense eosinophils (Fukuda & Gleich, 1989). 100 glml cells, a leftward shift in the density distribution of the BAL eosinophils towards lower densities was observed. 01; Kruskal-Wallace ANOVA). These results demonstrate that among the BAL eosinophils obtained during the late-phase response, hypodense cells constitute a significantly higher proportion. , 1984). The nature of this density heterogeneity and the mechanism(s) underlying the development of hypodense eosinophils is not yet known.

ECP has also been shown to cause a concentration-related damage to guinea pig tracheal epithelium as assessed by inverted microscopy. , 1989). , 1990). Interestingly, addition of catalase, which breaks down hydrogen peroxide, partially prevented the reduction in both ciliary beat frequency and area of damaged epithelium (Fig. 1). These data suggest, that in addition to the damaging effects of the basic proteins, oxygen radicals such as hydrogen peroxide may also contribute significantly to the toxic capacity of eosinophils.

35. 36. 37. 38. 39. 31 phils by eosinophil granule major basic protein: Effect on superoxide anion generation and lysosomal enzyme release. J Immunol145: 2626-2632 Kita H, Ohnishi T, Okubo Y, Weiler D, Abrams JS, Gleich OJ (1991) Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. J Exp Med 174: 745-748 Desreumaux P, Janin A, Colombel JF, Prin L, Plumas J, Emilie D, Torpier G, Capron A, Capron M (1992) Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

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Asthma: Immunopathology and Immunotherapy / Immunopathologie und Immunotherapie by Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke (auth.), Univ.-Prof. Dr. Friedrich Kummer (eds.)

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