Download PDF by Bodh I. Jugdutt: Aging and Heart Failure: Mechanisms and Management

By Bodh I. Jugdutt

ISBN-10: 1493902679

ISBN-13: 9781493902675

ISBN-10: 1493902687

ISBN-13: 9781493902682

This booklet synthesizes the main learn advances in molecular, biochemical and translational facets of getting older and center failure during the last 4 many years and addresses destiny instructions in administration and drug discovery. It provides scientific matters and molecular mechanisms concerning middle failure, together with the altering demographics within the getting older inhabitants with center failure; high blood pressure and prevention of diastolic center failure within the getting older inhabitants; polypharmacy and hostile drug reactions within the getting older inhabitants with middle failure; alterations within the middle that accompany advancing age from people to molecules; aging-associated changes in myocardial irritation and fibrosis and aging-related alterations in mitochondrial functionality and implications for middle failure remedy. The publication succinctly summarizes the massive quantity of information on those key themes and highlights novel pathways that must be explored. that includes contributions from major clinician-scientists, Aging and middle Failure: Mechanisms and Management is an authoritative source at the significant scientific matters in center failure remedy within the aged for cardiologists, gerontologists and internists.

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Extra info for Aging and Heart Failure: Mechanisms and Management

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2011;57(20): 2037–114. Tehrani F, Phan A, Chien CV, Morrissey RP, Rafique AM, Schwarz ER. Value of medical therapy in patients >80 years of age with heart failure and preserved ejection fraction. Am J Cardiol. 2009;103: 829–33. Orn S, Dickstein K. How do heart failure patients die? Eur Heart J. 2002;4(Suppl D):D59–65. Mozaffarian D, Anker SD, Anand I, et al. Prediction of mode of death in heart failure: the Seattle Heart Failure Model. Circulation. 2007;116:392–8. Cheitlin MD, Gerstenblith G, Hazzard WR, et al.

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Eur J Heart Fail. 2008;10:933–89. McMurray J, Adamopoulos S, Anker S, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 – the task force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology.

Clinical research on aging. Strategies and directions. N Engl J Med. 1977;297:1332–6. I. Jugdutt 52. Wenger NK, editor. Inclusion of elderly individuals in clinical trials. Cardiovascular disease and cardiovascular therapy as a model. Kansas City, MO: Marion Merrell Dow; 1993. 53. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat res. 1991;256:271–82. 54. Vaziri H, Dragowska W, Allsopp RC, et al. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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Aging and Heart Failure: Mechanisms and Management by Bodh I. Jugdutt


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