By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been performed as a rule from the his tological and biochemical points of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical tension has been proven to be the vital consider the initiation of osteoarthritis. even if the precise technique in which mechanical tension ends up in the complete destruction of cartilage tissue continues to be doubtful, a number of new learn equipment have enabled us to achieve a deeper figuring out of the method of degeneration. In October 1997, we geared up a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most themes being up to date re seek, analysis, and therapy of osteoarthritis. The court cases of the symposium are awarded right here in 5 sections: (1) Mechanical rigidity and reactions of chondrocytes, corresponding to intracellular ion adjustments, adjustments within the cytoskeleton, intracellular messenger structures, liberate of fuel mediators, and adjustments in electromechanical homes of cartilage; (2) sensible prognosis of osteoarthritis through MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) therapy with a promising basic washout procedure and IL-1RA and MMP antagonists; (4) Cartilage fix by way of new grafting tech niques; and (5) difficulties following overall joint substitute. We clearly desire that the complex wisdom supplied during this quantity of lawsuits may be beneficial to our readers.
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Extra info for Advances in Osteoarthritis
J Cell Sci 107:2033-2045 35. Newman P, Watt FM (1988) Influence of cytochalasin D-induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes. Exp Cell Res 178:199-210 36. Fukuda K, Dan H, Tanaka S, et al (1994) Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage. Agents Actions 42:71-73 37. Fukuda K, Kumano M, Tanaka S, et al (1995) Zonal difference of nitric oxide synthesis with interleukin-1 in bovine chondrocytes. Inflamm Res 44:434-437 38.
S-Hz cycle was applied with S-MPa pressure. OS-Hz loading cycles. In the longer pressurizations for 20h (Fig. 1, filled symbols), increased [35 S]sulfate incorporation in chondrocyte mono layers was found with the same cycles and pressures that were inhibitory in short-term experiments. 0167 Hz, there were no alterations in [35 S]sulfate incorporation . A continuous, 30-MPa hydrostatic pressure remarkably inhibited sulfation, glycosylation, and protein synthesis as measured by incorporations of [35 S]sulfate, [3H]glucosamine, and 4 C]leucine, respectively [4S].
25-Hz cycle. The stimulation took place through the whole depth of the cartilage. 5 Hz, reduced the stimulation, particularly in the superficial parts of the articular cartilage. As the strain of the cartilage in the directly loaded area was minimal (1 %2 %) with the short peak- loading pulse (50 ms) used, the stimulation of [ 35 S]sulfate incorporation was probably caused by enhanced hydrostatic pressure. J. Parkkinen et al. processing of the core protein was involved, including GAG assembly and sulfation in the endoplasmic reticulum and the Golgi apparatus, rather than enhanced transcription.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)